A variety of cardiovascular disease (CVD) statin prescribing strategies are advocated for use in primary care. We defined four strategies: assorted drugs and doses (current practice); fixed doses targeting all men or women aged >55 years; targeting those at high Framingham CVD risk; and tailoring dose according to risk stratification. By combining price and potency data with our CVD patient risks database, we modelled potential benefit (myocardial infarctions [MIs] prevented), cost and numbers expected to be treated for each strategy.