Asthma is a chronic disease that has, for a long time, been the domain of primary care nurses, and many have qualifications enabling them to run nurse-led asthma clinics. It is, therefore, essential to fully understand the Quality and Outcomes Framework (QOF) and to be able to maximise the points available to the practice, at the same time as providing a comprehensive service to patients. In this article, we review the QOF indicators for asthma, strategies for optimising record keeping and performing asthma reviews.