Feel the fear and do it anyway.’ That could be the message of this special issue of the British Journal of Primary Care Nursing focusing on chronic kidney disease (CKD). Kidneys can be really confusing for practice nurses, with lots of technical sounding tests and numbers. But the good news is that the step-by-step guides and clear articles in this issue will help you get to grips with this important condition and feel empowered to make a real difference to the health and wellbeing of your patients.