Chronic liver disease is a problem for all of us. It develops silently, often taking many years to cause sufficient damage to be detectable or cause signs or symptoms for which a patient would seek attention. Primary care has a central role in improving the prevention and early detection of chronic liver disease. This special issue of the British Journal of Primary Care Nursing (BJPCN) and Primary Care Cardiovascular Journal on chronic liver disease is full of step-by-step guides and informative articles to give you the key information and tools to get to grips with this important condition.