Chronic kidney disease (CKD) is characterised by irreversible renal scarring. Nephrologists draw the distinction between primarily glomerular scarring (glomerulosclerosis) and scarring centred on the kidney tubules (chronic tubulointerstitial nephritis). However, in clinical practice, glomerulosclerosis is by far the most common pattern in CKD and this article will focus on this type of renal injury.
The pathophysiology underlying chronic kidney disease
Diagnosing and monitoring CKD in practice
Diagnosing chronic kidney disease (CKD) and monitoring kidney function are key steps in improving management. This article reviews the recommendations on making a diagnosis of CKD, including staging patients, and the tests available for monitoring kidney function, with explanations of how to test patients, what the findings mean, and how to act on the findings.
The cardiovascular implications of chronic kidney disease
Chronic kidney disease (CKD) is a cardiovascular condition, with cardiovascular causes and consequences. The kidney complications are relatively uncommon. Until recently, many clinicians, let alone the public, were unaware of the high prevalence of the disease and its accompanying morbidity. The National Institute for Health and Clinical Excellence (NICE), through the National Collaborative Centre for Chronic Conditions, recently reviewed the available evidence and published a guideline to assist early identification and management of CKD.
Optimising the management of chronic kidney disease in clinical practice
Chronic kidney disease (CKD) is now recognised as a significant public health problem and various mechanisms have been put in place to identify people at risk. CKD overlaps with other chronic diseases, including diabetes and hypertension, and should not be managed in isolation. Vascular risk assessments are coming into place for the general population and there are strong links with vascular and kidney disease. CKD is becoming an integral part of chronic disease management.
Chronic kidney disease management in southeast England: a preliminary crosssectional report from the QICKD
Chronic kidney disease (CKD) is an important cause of mortality and morbidity, especially in people with cardiovascular disease. Interventions that can be delivered in primary care have the potential to slow the progression of the disease. People with CKD can be identified readily and reliably from GP computer systems. To report the baseline quality of CKD management. Pseudonymised routinely collected data from a representative sample of 14 practices across Surrey were extracted as part of a quality improvement study. The crude and adjusted prevalences of stage 3 to 5 CKD are 6.3% and 5.8%, respectively. More than twice as many females (8.8%) as males (3.9%) have this condition. Hypertension, diabetes, ischaemic heart disease and other cardiovascular disease and anaemia are much more common with deteriorating renal function. The reported prevalence is lower than suggested by previous studies but this may reflect the lower levels of cardiovascular disease associated with a healthier lifestyle in the Southeast. However, there is scope to further improve the quality of CKD management in Surrey. Programmes carefully targeted at high-risk groups could slow the progression of CKD and therefore reduce the need for renal replacement therapy.
CKD as part of integrated management of vascular risk
The urine tells a tale
Individualising patient care with the new NICE guideline
In 2008, NICE published a comprehensive guideline on the management of type 2 diabetes which took a patient-centred approach to care and updated recommendations on the management of blood glucose, blood pressure, lipids, thrombosis, renal function and retinopathy. A number of new and emerging therapies for blood glucose management were not included at the time and the recent publication of NICE Clinical guideline 87 provides valuable recommendations on when and where these drugs should be used in the care pathway. They give more options for healthcare professionals and their patients with type 2 diabetes at a time of ongoing change in management of the condition.
Achieving effective lipid management in diabetes
People with type 2 diabetes are at an increased risk of cardiovascular disease (CVD), and management of diabetic dyslipidaemia is an essential part of diabetes management. The Joint British Societies’ 2 (JBS2) guidelines established the lipid targets of 4 mmol/L for total cholesterol and 2 mmol/L for LDL-cholesterol for people with type 2 diabetes and those with CVD. These lower targets for people with CVD were adopted by the NICE lipid modification guideline (CG67) in 2008, and the new NICE guideline for the management of type 2 diabetes continues this emphasis on lower lipid targets.
New drugs and where they fit in the treatment algorithm
In May 2009, NICE published recommendations on the use of newer agents for the control of blood glucose in type 2 diabetes. This guideline provides a partial update for NICE Clinical Guideline 66 on the management of type 2 diabetes that was published last year. These newer agents include the dipeptidyl peptidase-4 (DPP-4) inhibitors, thiazolidinediones (TZDs), the glucagon-like peptide-1 (GLP-1) mimetic exenatide and the long-acting insulin analogues (insulin detemir and insulin glargine).