This case study describes the diagnosis and management of a 42-year old male patient with high cardiovascular risk and statin intolerance. He first became aware of high cholesterol at the age of 17 when his father, who was then 42 years old, had a myocardial infarction and he and his siblings had their cholesterol tested on the advice of their father’s cardiologist. Although his previous doctor advised him to take lipid-lowering medication he only did so briefly several years ago as he felt the medication ‘did not agree with him’ and he thought it not necessary because he was a non-smoker and exercised regularly.