The long-awaited Joint British Societies’ consensus recommendations for the prevention of cardiovascular disease (JBS3) were issued at the end of March. This launch came nine years after publication of JBS2, which caused much debate about recommended lipid targets of 4.00 mmol/l and 2.00 mmol/l that were subsequently endorsed by NICE. So what are the most important new recommendations from JBS3, and what will they mean for our patients and our clinical practice?